Publications

Smedowski A, Leopold A, Steplewska K. Characteristic features of carcinoids diagnosed in Department . Ann. Acad. Med. Siles. 2009, 63(4): 46-52

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.

Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxid Med Cell Longev. 2018 May 21;2018:8476164. doi: 10.1155/2018/8476164. eCollection 2018

Kokot J, Dobrowolski D, Lyssek Boron A, Milka M, Smedowski A , Wojcik L, Wowra B, Wylegała E: New approach to diagnosis and treatment of Acanthamoeba keratitis systematic review of literature. Klin Oczna, 4/2012, 311 317

Wylęgała E, Smedowski A , Wroblewska Czajka E, Nowinska A, Tarnawska D. Neurotrophic keratitis aetiopathogenesis, diagnostics and therapeutic options. Magazyn Lekarza Okulisty 2013, 7(6): 272 279.

Aragona P, Wylegala E, Wroblewska Czajka E, Smedowski A , Nowinska A, Roszkowska AM, Pisani A, Micali A, Puzzolo D. Clinical, confocal, and morphological investigations on the cornea in human mucopolysaccharidosis IH S. Cornea. 2014 Jan;33(1):35 42.

Smedowski A , Weglarz B, Tarnawska D, Wylegala E: Comparison of three different methods of Intraocular Pressure (IOP) measurements in cluding biomechanical properties of the cornea. Invest Ophthalmol Vis Sci. 2014 Feb 4;55(2):666 73.

Smedowski A , Pietrucha Dutczak M, Kaarniranta K, Lewin Kowalik J: A rat experimental model of glaucoma incorporating rapid onset elevation of intraocular pr essure. Sci Rep. 2014 Aug 1;4:5910.

Smedowski A , Paterno JJ, Toropainen E, Sinha D, Wylegala E, Kaarniranta K: Excipients of preservative free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE 2 corneal epithelial cells. Journal of Biochemical and Pharmacological Research, 2014; 2:175 184.

Smedowski A, Pietrucha Dutczak M, Kaarniranta K, Lewin Kowalik J. A rat experimental model of glaucoma incorporating rapid onset elevation of intraocular pressure. Sci Rep. 2014 Aug 1; 4:5910. doi: 10.1038/srep05910. PMID: 25081302; PMCID: PMC4118189.

Kaarniranta K, Szalai E, Smedowski A , Hegyi Z, Kivinen N, Viiri J, Wowra B, Dobrowolski D, Modis L Jr, Berta A, Wylegala E, Felszeghy S. A novel proteotoxic stress associated mechanism for macular corneal dystrophy. Histol Histopathol. 2015 Aug;30(8):921 30. doi: 10.14670/HH 11 588. Epub 2015 Jan 19.

Smedowski A , Wylegala E, Wojcik L, Tarnawska D. Atypical regressive corneal endothelial cysts in long term confocal follow up: a case report. Medicine (Baltimore). 2015 Mar;94(9):e564.

Smedowski A, Mikus Zagorska K, Jakubowska A, Piotrowska Gwozdz A, Piotrowska Seweryn A, Orchel P, Pojda Wilczek D. Different Impacts of Luminosity on Contrast Vision in Eyes with Transparent Optic Media and with Cataract Simulation. Med Princ Pract. 2015;24(6):501 8. doi: 10.1159/000433489. Epub 2015 Jun 26. PMID: 26138773; PMCID: PMC5588271.

Smedowski A , Liu X, Pietrucha Dutczak M, Matuszek I, Varjosalo M, Lewin Kowalik J. Predegenerated Schwann cells a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity. Sci Rep. 2016 Apr 1;6:23187.

Trzeciecka A, Paterno JJ, Toropainen E, Koskela A, Podracka L, Korhonen E, Kauppinen A, Kaarniranta K, Smedowski A. Long ter m topical application of PF prostaglandin analogues evokes macrophage infiltration in the ocular adnexa. Eur J Pharmacol. 2016 Jun 9;788:12 20.

Smedowski A , Tarnawska D, Orski M, Wroblewska Czajka E, Kaarniranta K, Aragona P, Wylegala E. Cytoarchitecture of epithelial inflammatory infiltration indicates the etiology of infectious keratitis. Acta Ophthalmol. 2017 Jun;95(4):405 413. doi: 10.1111/aos.13363.

Smedowski A , Tarnawska D, Kaarniranta K, Wylegala E. Longitudinal observation of the retinal nerve fibr e layer in glaucoma patients treated with brimonidine combined with timolol or timolol alone. Ophthalmol.J.2017; Vol.2, No.1, p.13 16.

Smedowski A , Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha Dutczak M, Lewin Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells A possible sign of endogenous neuroprotection failure. Biochim Biophys Acta. 2018 Jan;1864(1):296 306.

Pietruch a Dutczak M, Smedowski A , Liu X, Matuszek I, Varjosalo M, Lewin Kowalik J. Candidate proteins from predegenerated nerve exert time specific protection of retinal ganglion cells in glaucoma. Sci Rep. 2017 Nov 6;7(1):14540. doi: 10.1038/s41598 017 14860 5.

Smedowski A , Pietrucha Dutczak M, Maniar R, Ajeleti M, Matuszek I, Lewin Kowalik J. FluoroGold labeled organotypic retinal explant culture for neurotoxicity screening studies. Oxid. Med. Cell. Longev. 2018; Vol.2018, ID 2487473, p.1 11.

Marchesi N, Thongon N, Pascale A, Provenzani A, Koskela A, Korhonen E, Smedowski A , Govoni S, Kauppinen A, Kaarniranta K, Amadio M. Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE 19 Cells by Triggering Erk1/2, p38MAPK, and JN K Kinase Pathways. Oxid. Med. Cell. Longev. 2018; Vol.2018, ID 4956080, p.1 11.

Amadio M, Kaarniranta K, Xu H, Smedowski A , Ferrington DA. Molecular Mechanisms Underlying Age Related Ocular Diseases. Oxid Med Cell Longev. 2018 May 21;2018:8476164. doi: 10 .1155/2018/8476164. eCollection 2018

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A , Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen A K, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF 2 and PGC 1α genes leads to retin al pigment epithelium damage resembling dry age related macular degeneration. Redox Biol. 2019 Jan;20:1 12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.

Pietrucha Dutczak M, Amadio M, Govoni S, Lewin Kowalik J, Smedowski A . The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration. Front Neurosci. 2018 Nov 15;12:834. doi: 10.3389/fnins.2018.00834. eCollection 2018. Review.

Smedowski A , Akhtar S, Liu X, Pietrucha Dutczak M, Podracka L, Toropainen E, Alk anaan A, Ruponen M, Urtti A, Varjosalo M, Kaarniranta K, Lewin Kowalik J. Electrical synapses interconnecting axons revealed in the optic nerve head a novel model of gap junctions’ involvement in optic nerve function. Acta Ophth. 2019 Oct 10. doi: 10.111 1/ aos.14272.

Almubrad T, Mencucci R, Smedowski A, Samivel R, Almutleb E, Alkanaan A, Khan AA, Masmali A, Akhtar S. Ultrastructural study of collagen fibrils, proteoglycans and lamellae of the cornea treated with iontophoresis UVA cross linking and hypot onic riboflavin solution. Saudi J Biol Sci. 2021 Dec;28(12):7160 7174. doi: 10.1016/j.sjbs.2021.08.019. Epub 2021 Aug 10. PMID: 34867019; PMCID: PMC8626267.

Pacwa A Machowicz J Wojtyniak A Pietrucha Dutczak M Toropainen E Koskela A , Mrukwa Kominek E Lewin Kowalik J Smedowski A. SCD1 Fatty Acid Desaturase Inhibitor MF 438 Alleviates Latent Inflammation Induced by Preservative Free Prostaglandin Analog Eye Drops. Journal of inflammation research vol. 15 793 806 . 8 Feb. 2022, doi:10.2147/JIR.S347784.

Akhtar S , Samivel R Smedowski A, Alkanaan A Masmali A Kirat O , Ali Kha n A Almubrad T. A unique pre endothelial layer at the posterior peripheral cornea: ultrastructural study. Scientific reports vol. 12,1 2556. 15 Feb. 2022, doi:10.1038/s41598 02 2 06552 6